TY - JOUR TI - Cyclophosphamide related toxicity; a systematic review A1 - Alrefaei, Ahmed Eissa A2 - Alzahrani, Meshael Ahmed A3 - Alsuhaim, Sultan Abdulrahman JF - International Journal of Medicine in Developing Countries JO - IJMDC SN - 1658-7820 VL - 6 IS - 5 SP - 740 EP - 747 Y1 - 2022 AB - Cyclophosphamide is an alkylating agent that has been used for the treatment of severe manifestations of autoimmune inflammatory disease. Cyclophosphamide is widely used for the treatment of malignancies; it exerts its impact through the cessation of cell division. Cyclophosphamide is similar to other chemotherapies and has various toxicities; however, its toxicity is not well reported. This review was conducted to find out cyclophosphamide-related toxicities as reported in the previous studies conducted on that subject. A total of 91 articles were obtained, but only six studies were eligible for the inclusion criteria. The studies included a total number of 3,531 participants. Cyclophosphamide was associated with various toxicities, including liver toxicity, urotoxicity, cardiac toxicity, hematological, and non-hematological toxicities. The toxicity of cyclophosphamide varied based on the regimen and combined medications, as well as some gene variants. PB - https://www.ijmdc.com DO - 10.24911/IJMDC.51-1641243189 UR - https://www.ijmdc.com/?mno=140403 ER -